[garganzol]

If you talk about ME/CFS, then it is known to be helpful in some specific cases, but not universally. People with ME/CFS tend to be driven by autoimmunity as a primal factor of the disease.

There is a clear problem of diagnosis and intersection of the symptoms. What we call ME/CFS today may be several distinct diseases with overlapping symptoms.

To give you a direct answer: it helps with chronic fatigue, but only if one of the causes of the illness has a metabolic impairment component in it. Otherwise, no improvements are observed.