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by danenania 508 days ago
Gain-of-function in the virology context doesn’t mean creating helpful microbes/viruses. It means purposely engineering pandemic-caliber viruses so that (the theory goes) we find them before evolution produces them naturally and so have time to study them and create vaccines before they are widespread.
2 comments
sleeplessworld 508 days ago
This seems to be one of the most dangerous propositions that I have ever heard of. Given human history, human psychology, human error, politics etc.

What am I missing here? That biolabs are the only human made thing that can be made absolutely 100% secure?

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Izkata 508 days ago
As far as I know you're not missing anything and this is why gain-of-function research was banned in the US for a while. EcoHealth Alliance outsourced it to China in the mid-2010s because of the ban, so technically none of it was happening in the US.
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llamaimperative 508 days ago
> It means purposely engineering pandemic-caliber viruses

This is not true.

GoF includes any research that amplifies specific characteristics. Transmissibility or severity of infection are just two of those possible dimensions.

For example, the research that enables us to produce insulin (and tons of other biologic medicines) with E. coli is GoF.

I lean on the side of banning GoF that's designed to increase transmissibility of a contagion, but that is indeed just a subset of GoF generally.

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danenania 507 days ago
Fair enough that it has that meaning more generally in biology. My point is 100% of the policy discussions about it are referring to that particular subset—no one means producing insulin when they talk about the risks of GoF.
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llamaimperative 507 days ago
Yes but this is what causes confusion when scientists push back against proposed bans which seems like a legitimately insane and evil position to take.

We can sharpen the language and say "ban GoF research that increases transmissibility of infectious disease", for example.

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tripletao 507 days ago
I think the best term of art is ePPP (enhanced potential pandemic pathogens), which clearly limits that scope. Academics use that reasonably often, though politicians and the general public unfortunately don't yet.

There's also GOFROC (gain of function research of concern). That's better than just GOF, but rather vague.

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llamaimperative 507 days ago
This is useful! Thank you for chiming in :)
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