[zmgsabst]

I phrased that poorly:

I understand how WIV could have caused a pandemic, but I don’t understand the other direction — how WIV doing gain-of-function would help the situation in which there was a zoonotic origin, eg at the wet market.

The person I was replying to said that our opinion on gain-of-function should depend on the origin — but I don’t understand how gain-of-function would have helped at all. Only how it poses a risk, whether or not this particular virus was such an example.

[theptip]

The theory is quite clear, if you know which strains could hop to humans then you can prioritize monitoring them, just like we monitor influenza types in animal populations now.

The problem is just that P(avert catastrophe) is fairly low, and P(create catastrophe) is substantially higher.

[gardnr]

Oh, now I see what you mean.

I am not in the sector but AFAIK there has been no direct benefit from GoF. There is huge potential which some experts believe outweigh the risks, which is why it is controversial, and that is why it has been politicized.

Protecting the funding and ability to continue the research would explain why scientists have a preference for spillover as opposed to leak. Then there are the politicians...