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by prerok 522 days ago
Hmm, I understand this difference in genes differently.

You and I probably share 99% of effective genes, but still the difference in genes is much greater because there we are comparing the entire DNA. There is a lot of non-affecting DNA. And that is what they analyze when comparing DNA of two individuals in forensics.

1 comments

Based on the information I found, the % difference between two randoms humans in terms of base pairs (including non-coding DNA) is even less than the difference in terms of genes, so the distinction does not materially alter the discussion. Also the article framed its explanation in terms of genes, not base pair sequence.

"Between any two humans, the amount of genetic variation—biochemical individuality—is about .1 percent." https://www.ncbi.nlm.nih.gov/books/NBK20363/

https://book.bionumbers.org/how-genetically-similar-are-two-...

Forensic comparisons are mostly about comparing the number of short tandem repeats at handful of loci, a very small part of the the whole genome.

If you have any information that indicates the DNA similarity between people is less than 98–99% I would love to hear it. I have not personally analyzed the sequences from the 1000 genome project to check, and am relying on summaries written by other people.

I see, thank you for the explanation!