[vidarh]

I used a single user instance, and it's perfectly viable. If anything it's less hassle with respect to blocks.

Relays can also easily mitigate the issue you describe, as can an algo provider that simply boost all entries it puts in your feed.

[meatmanek]

I also run a single-user instance, and it's fine. Maybe I'm not prolific enough or marginalized enough to attract much attention, but I've only had to block one person in 2 years.