[twasold]

This needs (2015). Surely if ultrasound was effective in replicated studies we’d have a treatment by now, right? Or have heard more about it?

[YZF]

This assumes anyone attempted to replicate it or otherwise pursue it. I guess the question would be where are the studies that failed to replicate it.

I have friends that work in the medical tech field. A device they started developing around 2009 is barely getting into the field now after animal trials and clinical trials around the globe. It's an extremely long process requiring a lot of capital. And you likely haven't heard of it either (it is pretty effective for treating some heart related issues).

There are plenty of animal studies that show some promise that are simply abandoned for various reasons.

All that said, I thought the hypothesis that those amyloids are the cause of Alzheimers hasn't really worked out, there were other drugs that targetted those and apparently didn't work that well.

[boxed]

https://link.springer.com/article/10.1186/s13195-021-00809-4 (2021) is the second hit on google scholar. Sounds a bit more involved than just ultrasound.

https://link.springer.com/article/10.1186/s13195-022-00981-1 sounds mildly promising in one way, and disappointing viewed another way...

[pstuart]

It takes a long time to go from the lab to commercialized use.