[robg]

Nedergaard (lab head here and main findings of this effect since 2012) is going to win the Nobel for this line of research. When I got my Ph.D. 20 years ago in cognitive neuroscience we knew three main deficits to a lack of sleep but couldn’t connect them mechanistically: 1) loss of daily performance metrics 2) increased risks of mental health concerns 3) increased risks of cognitive declines

The glymphatic nervous system, like any great scientific theory, unites disparate findings under a common mechanism. Not getting enough sleep is akin to not running your dishwasher or washing machine long enough, the gunk accumulates.

And for all the parents out there, pediatric recommendation is 10-12 hours a night for kids 6-12 years old and 8-10 hours a night for kids 13-18 years old.

[dogcomplex]

Recommended hours not nearly hit enough when they have to finish the night's homework then catch the 7am school bus...

[adsteel_]

It makes me think of long COVID and CFS, where patients complain of a lack of "unrefreshing sleep" and "brain fog". A lack of perfusion resulting in waste not being sufficiently flushed out could possibly result in those symptoms.