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by tootie 521 days ago
Intractable sleep conditions exist. I have narcolepsy which is incurable. I'm on sodium oxybate which is basically just GHB. It's a "scary" drug to be taking every night, but it's very effective and usually very safe in controlled dosage.
1 comments

That drug is not a drug designed to put you to sleep though (I mean it kinda does, but that's not its purpose). The purpose of that drug is to change your sleep architecture during the night. I'm on the newer form of that drug (because of idiopathic hypersomnia) and most nights I still take 1–2 hours to fall asleep.
Lumryz? GHB is metabolized very quickly and would be out of your system within 2 hours. Lumryz is supposed to process slower. I have had a few bad nights on xyrem, but mostly it puts me sleep quickly enough. And more importantly puts me on a better sleep cycle so I'm actually sleepy at bed time by dint of being awake during the day.
Xywav, with the 2-dose schedule. My impression based on how I feel waking up at various times in the morning is each dose produces effects that last somewhere around 3–5 hours. My understanding is most people taking this drug are falling asleep much more quickly than I am, and I do feel it trying to make me sleepy shortly after taking it, but not enough to defeat my delayed sleep phase disorder and various insomnia issues. But my point was that "falling asleep quickly" is not a direct goal of the drug, even if it is a common effect, the goal of the drug is to change what your brain does while you're asleep.