[aziaziazi]

I’m not an expert but a quick search leads me to:

> We identify NAS-altered microbial metabolic pathways that are linked to host susceptibility to metabolic disease, and demonstrate similar NAS-induced dysbiosis and glucose intolerance in healthy human subjects. Collectively, our results link NAS consumption, dysbiosis and metabolic abnormalities, thereby calling for a reassessment of massive NAS usage

I’d be glad to see the full paper

https://pubmed.ncbi.nlm.nih.gov/25231862/

> normal soda consumption levels in humans

I note that "normal" here should be read as "common during the last 50years (or less)", where the last 50ears is quite reductive in human dietary habits.

[Laforet]

This paper you linked does not even involve aspartame. The only sweetener they experimented with is saccharin. You can check out the main figures from the link below:

https://www.researchgate.net/publication/265791239_Artificia...

I would be very reluctant to read too deep into this given saccharin is known to behave very differently in animal models - for a long time it was thought to cause bladder cancer, but follow up studies proved that it’s an idiosyncratic reaction only found in female lab rats and no other gender/species combination. Not to mention the dose used was unrealistic to begin with.

It’s entirely plausible that sugar analogs like sucralose and non-calorific sugar alcohols such as erythritol and maltitol can cause long term changes in the gut biome but high quality evidence is still lacking.