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by fastaguy88 546 days ago
Early studies (1970's and earlier) used the antigen (hapten) di-nitro-phenol (DNP) to explore antibody diversity (how many different antibodies might be raised against a simple small molecule). DNP is very simple (non-chiral) structure that generates a diverse set of antibodies.

Whether an antibody raised against one structure interacts with a different structure is irrelevant to the question of whether an antibody can be raised to the other structure.