[mezzie2]

There's also a certain amount of tolerated variance in generic drug manufacture. Sometimes this isn't a big deal, but other times it can be a problem. For example, if my generic tizanidine (muscle relaxant) is 10-20% less or more effective, it's not really a big deal: I get a little sleepy or need to take an extra pill. When I was on duloxetine for nerve pain, though, I could feel the swings/differences in generics and it was a major problem.