A lot of the so-called "water washable" bio resins need to be diluted down to 1L of resin + 1 million L of clean water before they are considered safe enough that you're allowed to flush them down the toilet. So I would never touch them without gloves.
And while you are correct that some plant-based resins are not a class 3 lung poison anymore, they are still a class 2 eye irritant and can cause burns in your eyes purely through aerial exposure. Which means you need to wear goggles whenever you're in the same room.
It's similar to 2 component epoxy: The raw materials are highly poisonous, but the reaction end product is safe. It's just that you need to be 100% sure that there are no un-reacted resin leftovers anywhere on your part. And that part is very difficult.
And while you are correct that some plant-based resins are not a class 3 lung poison anymore, they are still a class 2 eye irritant and can cause burns in your eyes purely through aerial exposure. Which means you need to wear goggles whenever you're in the same room.