| HN Mirror

Norwitz and Layne differ on the lean mass hyper-responder phenotype. Norwitz likes referencing his meta-analysis of 41 RCTs, but pay attention to its conclusion:

> A substantial increase in LDL cholesterol is likely for individuals with low but not high BMI with consumption of an LCD, findings that may help guide individualized nutritional management of cardiovascular disease risk. As carbohydrate restriction tends to improve other lipid and nonlipid risk factors, the clinical significance of isolated LDL cholesterol elevation in this context warrants investigation.

"warrants investigation"??? Come back when you have hard outcomes, i.e. reduced MACE. His meta-analysis of RCTs concludes that some people on keto have increased LDL! Norwitz admits in another video: "No, I'm not going to say that high ApoB is fine... ApoB is necessary but not sufficient [to cause ASCVD]" https://youtu.be/270ZyfSGLkE?t=484

So, what "humiliation"? If high ApoB (synonymous with LDL for our purposes) is bad, why would you go on a diet that causes it?

Layne has a large lay audience, and he has to stick to his main message: that w/r/t diet, calories are all that matter. Lowcarb/lowfat/vegan/whatever is fine. Platforming someone who's obsessed with LMHR is going to be too much biochemistry for Layne's audience. And for an effect that's relevant to perhaps only 2% of people? Low-carb advocates have their own YouTube channels; there's no reason Layne, as a center-aisle scientist, needs to engage.

Until the LMHR has been shown to have reduced MACE, which Norwitz admits we don't have evidence for https://www.youtube.com/watch?v=gxRLRYEQaEs&t=971s I don't see the point of Layne platforming him to just talk about biochemistry and confuse people.