[t-writescode]

You need to be in the same place, at the same time, every day, and always have them with you, continually. You also need to keep them dry and at room temperature all the time, so no leaving them in your car.

Here's another example of a pill that needs to be taken every day, at approximately the same time of day: https://www.plannedparenthood.org/learn/birth-control/birth-...

From this article on that pill,

> But people aren’t perfect and it’s easy to forget or miss pills — so in reality the pill is about 93% effective. That means about 7 out of 100 pill users get pregnant each year.

You mess up and you have HIV for life. It's better to have something that provides more stable protection :)

[2Gkashmiri]

https://en.m.wikipedia.org/wiki/Directly_observed_treatment,...

This is already possible by DOTS.

In India it did wonders

[slashnode]

DOTS is effective for TB because it’s a time-limited treatment (usually 4 months for drug susceptible strains of TB) and is only relevant for treating infected individuals

DOTS wouldn’t be feasible for a prophylactic treatment like this as the number of participants would be huge and the treatment period is indefinite (ie: the patient’s lifespan)

[saagarjha]

> Directly observed treatment

For a sexually transmitted disease? Harder than you'd expect, considering people are reticent about their private lives.

> short-course

This needs to be continued forever, as far as I understand.

[rcxdude]

It's also quite expensive