Reflex is a great project with a great feature set, it does everything (client rendering, state sync, API) and you can even write your callbacks in Python. It seems like the best option from this family of frameworks (alternative is NiceGUI for example, but having worked quite a bit with that, I probably wouldn't recommend it). Doing everything has some downsides though: there's a ton of "magic" under the hood, the lib is obviously very opinionated (it couldn't exist otherwise) and you may have a hard time if you need something that's not built in to the framework.
htmy is pretty much the opposite, it only does HTML rendering and comes with a set of utilities for advanced uses, e.g. async support, context usage, styled markdown, etc.. With FastHX, you also get a pretty convenient, declarative integration with FastAPI and HTMX. The tool is ergonomic, but you do need to put in more work compared to Reflex (create APIs, use HTMX, maybe AlpineJS or similar client-side tools). In exchange for simplicity (and lack of magic), you get full control over everything: you can convert your business objects to components, use any CSS/UI lib, any backend tooling. Extra benefit is you can migrate to (and from) it relatively easily from tools like Jinja.
Reflex is a great project with a great feature set, it does everything (client rendering, state sync, API) and you can even write your callbacks in Python. It seems like the best option from this family of frameworks (alternative is NiceGUI for example, but having worked quite a bit with that, I probably wouldn't recommend it). Doing everything has some downsides though: there's a ton of "magic" under the hood, the lib is obviously very opinionated (it couldn't exist otherwise) and you may have a hard time if you need something that's not built in to the framework.
htmy is pretty much the opposite, it only does HTML rendering and comes with a set of utilities for advanced uses, e.g. async support, context usage, styled markdown, etc.. With FastHX, you also get a pretty convenient, declarative integration with FastAPI and HTMX. The tool is ergonomic, but you do need to put in more work compared to Reflex (create APIs, use HTMX, maybe AlpineJS or similar client-side tools). In exchange for simplicity (and lack of magic), you get full control over everything: you can convert your business objects to components, use any CSS/UI lib, any backend tooling. Extra benefit is you can migrate to (and from) it relatively easily from tools like Jinja.