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"but there are substantial areas of future work." Well, yes. Most plant mass comes from air and water, not the ground. Carbon, hydrogen, oxygen, and nitrogen all come from the atmosphere. This is why farms don't dig themselves into the ground.
If air and water can be made from asteroids, that's most of the raw materials problem by quantity. Hydroponics already works. Direct synthesis of food from hydrocarbons has never really caught on, although it's been done experimentally and is an area of active research.[1] DARPA has a project.[2] "To address vulnerabilities in food supply chains across a variety of operational and humanitarian scenarios, Cornucopia will demonstrate the capacity to produce all four human dietary macronutrients (protein, carbohydrate, fat, and dietary fiber) in ratios that target Military Dietary Reference Intake (MDRI) daily requirements for complete nutrition. Outputs will be in multiple food formats (e.g., shake, bar, gel, jerky) that meet military nutritional standards and palatability requirements in a system minimizing inputs, handling, and footprint." [1] https://www.sciencedirect.com/science/article/abs/pii/S09242... [2] https://www.darpa.mil/program/cornucopia |
Reduced organic compounds, like hydrocarbons, are not food for plants, but for fungi or similar organisms, which, like humans, need only dioxygen from the atmosphere.
There already are genetically-modified fungi that can produce the complete proteins required by humans (i.e. whey proteins or egg-white proteins) when fed with cheap carbohydrates and ammonia or a simple amino-acid. There are also fungi that can feed on hydrocarbons.
Creating genetically-modified fungi able to feed on hydrocarbons and produce glucose and proteins for human consumption is not far from the already existing technology. With a serious effort in this direction, this could be solved in a decade or so. The glucose and proteins produced by fungi would be used not only for direct consumption, but also for feeding other microbial cultures that are needed for producing vitamins and essential fatty acids, using the techniques that are already in use today for this purpose.