[chiaro]

What struck me about that quote is that maybe he's approaching things from the wrong direction. Why make a dent in the universe? What explicitly do you hope to accomplish with that?

Not attacking personal philosophies here, but this seems to run along the same vein as the desire to be "famous for being famous". Focus on building something, on creation and life. All the dents you make will be relative anyway, because as many have said - there's always someone doing something better. First, know what you want to do, second, do it to the best of your abilities. The dent that makes on the world is dependent on a plethora of influences most of which will be beyond your control.