My experience with IntelliJ + a bunch of JS frameworks is that IDE-based browser debugging works quite well. Unfortunately, Firefox' remote debugging capabilities broke for me at some point, but adding a Chromium debug target in my IDE seems to work most of the time. As long as the Rube Goldberg machine that does JS transpilation includes a source map, frameworks just seem to work out of the box (as does raw JS, but that's not so common anymore).
That even includes debugging some languages compiled to WASM, like C#, interestingly enough.
That even includes debugging some languages compiled to WASM, like C#, interestingly enough.