[bsmartt]

damn this reddit thread is 3 months old? t1 here as well, and i struggle pretty bad. having been t1 for 20 years or more, i just can't click every article my friends and family send me promising progress for diabetics or potential cures. its just not worth getting my hopes up even when its a reputable outlet making some extraordinary claims. this sounds really promising but yea. its also depressing. its kinda too late to save me even if this comes very soon. which i doubt it will. However, this so called 'smart insulin' sounds to me much more like the shit produced by non-diabetics pancreases. like theres just no way the non-diabetic body is making a hormone that doesnt fully kick in for 90 minutes. that just wouldnt be as resilient and effective as what i witness in the people around me. its insane how they can, for example, eat a tub of ice cream on a whim and not be blasted into the 400s. or just go wild exercising at length on an empty stomach and not have an emergency low sugar.

[pimeys]

There's already software that can definitely mitigate these problems you've outlined. I've been using AndroidAPS together with Lyumjev insulin, an insulin pump and a Dexcom system for several years now. Yes, I can go running with an empty stomach and yes, I can have a nice dinner without being in the high 400's... My glucose hasn't really been above 200 for months, and the last time was a leaking tube in the pump. My A1c has been between 5.5 and 5.9% for many years now. There's no need for ambulance to come and rescue me due to hypoglycemia.

If you're in any way technical, you should take a look into the solutions for artificial pancreas.

[terminalcommand]

Another T1D here. I do not have a compatible pump with looping. But I'd like to dip my toe into openaps.

I use a cgm (libre2).

Can I use autotune to tune my carb ratio, basals etc. without looping? How was your experience in this?

Do I have to use nightscout to run autotune?

[pimeys]

I've run it against my nightscout data a few times to get insights to my profile. So yes, you should install it somewhere and run a CGM app such as xdrip which can transfer your libre2 data to your nightscout database.

So yes, if you are interested on autotune, a nightscout is required for now.

[haccount]

It kick in slowly because standard administration is subcutaneous which isn't a very well vascularized tissue.

If you shoot up in your veins or into something more vascular you would have faster onset.

[lolc]

I participated in studies where they administered insulin and glucose intravenously. It is wild how they can reliably drop my blood sugar from high to low within a few minutes. Subcutaneously this takes me hours to do in a stable way.

[user_7832]

Not only veins, inhalable insulin like Afreeza is also really quick. Unfortunately it only appears to be available in the US (and maybe Canada?), not Europe/Asia from what I last remember.

[protomolecule]

>If you shoot up in your veins

Which is a sure way to find yourself in a hypoglycemic coma.

[user_7832]

Inhalable insulin (which is also very fast acting) iirc only allows a dose of 2 units. If your sugars are 400mg/dl (22ish mmol/l) one or two doses wouldn't put you into a coma if you knew your sensitivity. I'm pretty sure I've read up T1s talking about using it as such.

[protomolecule]

Sudden drops of the blood glucose level aren't good for health.

[dazc]

'...its insane how they can, for example, eat a tub of ice cream on a whim and not be blasted into the 400s.'

No such thing as a free lunch, they are just building up insulin resistance with, eventually, Type 2 Diabetes a near certainty in later life.