[pdabbadabba]

> where the same problems are "simply" solved by getting on a calorie deficit and lean

Except that there apparently is mounting evidence that GLP-1 agonists also address some issues that are not generally addressed by just restricting calories. TFA touches on this briefly: "The weight loss involved with GLP-1 agonist treatment is surely a big player in many of these beneficial effects, but there seem to be some pleiotropic ones beyond what one could explain by weight loss alone."

I seem to recall seeing claims that they reduce COVID-19 mortality even controlling for BMI (possibly because they inhibit systemic inflammation), reduce alcohol consumption, and even (though I think just anecdotally) may help overcome gambling addiction.

See, for example:

https://pmc.ncbi.nlm.nih.gov/articles/PMC8425441/ [COVID-19]

https://www.ncbi.nlm.nih.gov/search/research-news/19361/ [Addiction]