I just listened to an in-depth analysis of this last night. All of these great effects can be explained by reduced caloric intake / weight loss / better glucose control. In other words - it just means it works as intended.
So while it's an amazing drug / new class of drugs, it probably will not lower risk of Alzheimer's in metabolically healthy people.
If it independently helps lower the risk of Alzheimer's even in people that are not diabetic and are of healthy body weight, then it might be worthwhile for those people to take.
If it's purely around the weight loss, etc., then it won't.
I don't think the comment was meant to minimize the impact of losing weight on health.
So while it's an amazing drug / new class of drugs, it probably will not lower risk of Alzheimer's in metabolically healthy people.