With how trivial generating new addresses in IPv6 is, it'd be cool to have a host block all incoming traffic on its own and have each service that deserves to be reached over the listen on an address unique to the service.
In a /64, enumerating all hosts will not be as practical as enumerating all ports on a single IP. Further, you will not be able to link that two services are running on the same host by just the IP.
It’s already a thing. These unique per-service addresses are called “ports” in IP protocol.