[hugohadfield]

You could almost certainly construct a convolutional kernal that computes smoothed derivatives of your function by the derivative of a gaussian smoothing kernal (that kind of technique is mostly used for images if I remember correctly ), in fact I recon this might work nicely https://docs.scipy.org/doc/scipy/reference/generated/scipy.n... although you would need to enforce equally spaces inputs with no misssing data. Alternatively you might also set up an optimisation problem in which you are optimising the values of your N'th derivative on some set of points and then integrating and minimising their distance to your input data, also would work well probably but would be annoying to do regularisation on your lowest derivative and the whole thing might be quite slow. You could also do B-splines or other local low order polynomial methods... the list goes on and on!