[playingalong]

> acknowledged that he had not been able to pinpoint Columbus’s place of birth

Nit pick.

I don't know it for sure, but if he was able to meet a king and a queen eventually, I assume he came from a wealthy family.

For wealthy families at that time, it wouldn't be an issue to travel. Especially if you turn out to be the most known traveler in human's history.

Thus, I fail to see how come we can even think of establishing the place of birth based on DNA. A likely area where his family came from - sure. But POB?