[ralferoo]

: is shifted on almost every keyboard layout, so saving or quitting would require at least one key combination (OK, arguably you can quit with caps lock, Z, Z, caps lock).

But I suspect he meant "sequence of keys" by "key combination" in what was clearly intended to be a humorous parody of the previous comment.

[xeeeeeeeeeeenu]

I always remap : (colon) to ; (semicolon) in vi clones to avoid having to use the shift key.