The extreme to which he is taking things and the level of rigor he is (seemingly) applying, are the differences I see. He has a lot more time and resources at his disposal than most wellness hackers.
Doesn't seem like it. He was doing most of what he claims years before he marketed anything. I remember him on Lex Friedman years ago talking about only eating one meal per day, eating as healthy as possible, optimizing his sleep, etc.