[CharlieDigital]

If you go to https://clinicaltrials.gov/, you can see almost every clinical trial that's registered in the US.

Some trials have their protocols published.

Here's an example trial: https://clinicaltrials.gov/study/NCT06613256

And here's the protocol: https://cdn.clinicaltrials.gov/large-docs/56/NCT06613256/Pro... It's actually relatively short at 33 pages. Some larger trials (especially oncology trials) can have protocols that are 200 pages long.

One of the big challenges with clinical trials is making this information more accessible to both patients (for informed consent) and the trial site staff (to avoid making mistakes, helping answer patient questions, even asking the right questions when negotiating the contract with a sponsor).

The gist of it here is exactly like you said: RAG to pull back the relevant chunks of a complex document like this and then LLM to explain and summarize the information in those chunks that makes it easier to digest. That response can be tuned to the level of the reader by adding simple phrases like "explain it to me at a high school level".

[theGnuMe]

What's your experience with clinical trials?

[CharlieDigital]

Built regulated document management systems for supporting clinical trials for 14 years of my career.

The last system, I led one team competing for the Transcelerate Shared Investigator Portal (we were one of the finalist vendors).

Little side project: https://zeeq.ai