Anything new or different is an uphill battle, but I have a hard time believing that anyone who has spent even the slightest amount of time with pip and conda, getting their python execution house of cards built.. just.. so.. is going to struggle with .net libraries and packages.
Edit: or do you mean the comparative lack of libraries?
Yes the comparative lack of libraries and also the roughness of existing ones. I've only toyed a bit with F#, but getting libraries to work that were designed for C# were a bit of a struggle unlike Python, were the resistance to get something to work the first time is low. The inconsistencies would turn up but usually much latter
Edit: or do you mean the comparative lack of libraries?