[jaggederest]

Actually went through fullgenomes.com - they apparently don't offer exome sequencing any more but for under $1200 getting your genome sequenced is interesting.

If you ask anyone who works in genetics, though, they'll advise you never to do it. It can be bad news, but there's virtually no good news there.

[dunk010]

It's useful to have as a resource that you can dip into; for instance to check a specific thing like "how fast do I metabolise caffeine (bad example as youc can get that from a SNV checking service like 23&Me. However, never ever EVER dump your whole genome into a program that will output every match for some potential condition. Now that's not for the reason you might immediately think ("Oh no look at all the bad stuff"), but rather because the databases that tools like this use are pretty chock full of junk where some researcher threw in a reference - along with a few thousand others - to say that their particular piece of research implicates this gene at this poistion with this variant. I've seen it with my own eyes, and a lot of it is very low quality. You therefore need highly curated databases where the genotype-phenotype associations are well-defined and thoroughly researched. You'll spend the rest of your life either trying to prove/disprove every potential false positive, or just worrying yourself needlessly. So, yeah, it's not a bad resource to have if you can be responsible with it.

[bick_nyers]

Hmm, now I'm interested in seeing if an LLM could be finetuned to give an effective quality score on such a study.

[FollowingTheDao]

I had mine run twice through 23andMe just to make sure they didn’t get something wrong. I tried to get my full genome once but the company screwed me over.

And I take exception to your “no good news”.

I discovered a gene polymorphism that led to the discovery the reason for my immune deficiency and mood disorder.

I found it gave me agency as well since I know that these genes are all risk genes and not fully determinant genes.

[jaggederest]

It's funny because your post in another thread is one of the reasons I brought it up here.

I would regard that as one of the exceptions in the "virtually no" caveat.

[bick_nyers]

Nowadays whole genome sequencing can be done for $300-400 (for 30x WGS, with 100x around $1000?), it's been on my TODO list for a few years.