[Kodiologist]

> Are there Python language features I can't use in Hy?

At the semantic level, no. I work to cover 100% of Python AST node types with Hy's core macros. It does take me a little bit to implement a new core macro after the CPython guys implement a new feature, but you can always use the `py` or `pys` macros to embed the Python you need, should it come to that.

> Or performance penalties in using Hy?

Compiling Hy (that is, translating it to Python AST) can be slow for large programs (I've seen it top out at about 3 seconds), but at runtime you shouldn't see a difference. Hy always produces bytecode, which can be used to skip the compilation step if the code is unchanged.