[maxerickson]

On average, the macros in an Office document add features to the software and aren't run to render any content. So like toggling a group of settings or inserting some content or whatever. They may change the content, but it's done at a point in time by the user, not each time the document is opened.

And then, on average, most users don't use macros in their documents.

So yes, negligible.