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by d_silin 648 days ago
...as difficult as discovering new medicines, you mean?

Chemistry and molecular biology are fiendishly complicated fields, far more complex and less predictable than what general (and most of the non-biochem STEM majors) imagine them to be.

How do I know? I thought of one brilliant startup idea that would solve so many of the world's problems if only we used computers to simulate biological systems.

Result: https://xkcd.com/1831/

Reference materials:

https://www.amazon.ca/Molecular-Biology-Cell-Loose-Version/d...

I strongly recommend to treat it as introductory-level text on the same level as "K&R - C Programming Language". Yes, all 1464 pages of it.

https://www.amazon.ca/Fundamentals-Systems-Biology-Synthetic...

On the same level as above text, but with more math.

https://www.amazon.com/Introduction-Computational-Chemistry-...

That or any other book on computational chemistry will give you an understanding why it is difficult to design anything of value in biological systems. ML can only help so much.

Also check out this page for entire field scope:

https://en.wikipedia.org/wiki/Omics

2 comments

MBoC is more like Knuth's textbooks. It's a towering monument to the achievements of humanity over the past 150 years (molecular biology proper is less than 100 years old). As well as being highly accessible (readable).

It's done in an interesting style, with lots of direct references to current literature. I was surprised to see a recent edition on IA: https://archive.org/details/alberts-molecular-biology-of-the...

Thank you for the textbooks! I've started studying Molecular Biology of the Cell to prepare for undergrad, but this is the first time I've heard about the others.

Are there any other books you would recommend?

Search for "computational biology" on Amazon, but I'd say go first to online courses if you have time and commitment, like:

https://www.coursera.org/specializations/bioinformatics

https://www.coursera.org/specializations/systems-biology

Also, checkout out

https://www.coursera.org/courses?query=computational%20biolo...

Then you will have a better understanding of the subject area and the literature to search.

I'm still in high school, so I don't think I'll have time to fit the courses into my schedule. I'll definitely look for the books though! Thanks.