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For what I read, the limiting factor is how quickly and easily I can grok what they are trying to communicate, not how quickly and easily I may be able to apprehend the letterforms.

Sure, there are better typographical choices than monospace, but even bothering with that decision is like optimising a 2*x to an x<<1 in code that's hitting disk anyway.

(on the flip side: it doesn't matter how easy it is to read a sequence of words, or how beautiful they may be, if they don't communicate anything; the code analogy is that it doesn't matter how much faster a buggy change runs)

Does that make sense?