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by AnthonBerg
665 days ago
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I know a lot of things are in mice; This is more than that. I wish to point out this passage from the paper as it stands on bioRxiv: “Here we report that KYN generated by IDO1 suppresses astrocytic lactate transfer to neurons in mouse models
of AD pathology and human iPSC-derived astrocytes from late-onset AD subjects.” https://www.biorxiv.org/content/biorxiv/early/2024/06/28/202... From reading the abstract and editor’s perspective, part of this seems to involve an unfortunate stimulation of kynurenine synthesis from tryptophan, which has deleterious effects on brain cell energy metabolism? It’s pretty interesting to just read the Wikipedia page on kynurenine with this perspective in mind: https://en.m.wikipedia.org/wiki/Kynurenine |
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