[hi-v-rocknroll]

There's really no good mechanical way to preferentially kill adipose visceral cells to prevent them from storing excess energy in the first place. It's mostly a cosmetic procedure to reduce subcutaneous adipose population with fewer risks than mechanical surgery, but I bet it has very slight benefits but not enough to equal clinical management of obesity.

Maybe in the future there will be a temporary immunotherapy target to get the immune system to attack adipose cells but then terminate/unlearn before it gets too carried away.

[carlmr]

>Maybe in the future there will be a temporary immunotherapy target to get the immune system to attack adipose cells but then terminate/unlearn before it gets too carried away.

Unlearning is usually not a thing for our immune system. I don't think this would even be the most promising target. Imagine being able to reverse autoimmune disorders.

[hi-v-rocknroll]

> Imagine being able to reverse autoimmune disorders

That would be awesome. Perhaps if it were possible dump the state of memory B cells (I'm wondering if flow cytometry can do this), classify and inventory immunoglobulins, filter them out via perfusion, and custom program naive B cells and add them back to the body. Memory T cell types seem way messier but some should be tunable with epigenetic levers. We will eventually learn how to hack the adaptive immune system, but it's going to take a lot of research time and effort to produce to a specific autoimmune therapy for a specific clinical problem likely customized to a single individual.