[lr4444lr]

does it cause the inability to eat an adequate amount of calories to function properly

IANAD, but anecdotally it has been seen that a substantial - and arguably worrisome - amount of the weight loss is in lean body mass[0], so probably. GLP-1 agonists are for many obese and at-risk diabetics a worthwhile trade-off. Losing that last pesky 10 lbs. because you don't want to give up your daily 500 calorie latte? Probably not.

[0] https://dom-pubs.onlinelibrary.wiley.com/doi/10.1111/dom.157...

[oarfish]

If you dont resistance train, any weight loss regimen will cause a loss of lean body mass, medications aren't different from an "organically" achieved caloric deficit. Training and size of the deficit as well as genetics heavily shift the proportion of adipose to lean tissue (which includes water) lost.

So far as i know, the signal that glp1 agonists are particularly worse for lean mass retention isn't strong enough to claim that they're worse for muscle mass retention than normal dieting.