They went with the premise of "a little a day seems to help, what happens if we feed ridiculous quantities once". The sort of medical research that appeals to the engineer in me and something you can only really do with compounds that are already known to be unlikely to kill your patient if you exceed the usual dose. Also I strongly suspect they did this to students given the age range.
There's more literature out there than this. That paper's references are probably a reasonable start point. But as creatine is very cheap and has been widely consumed by athletes for ages now it's about as low risk a gamble as any out there.
They went with the premise of "a little a day seems to help, what happens if we feed ridiculous quantities once". The sort of medical research that appeals to the engineer in me and something you can only really do with compounds that are already known to be unlikely to kill your patient if you exceed the usual dose. Also I strongly suspect they did this to students given the age range.
There's more literature out there than this. That paper's references are probably a reasonable start point. But as creatine is very cheap and has been widely consumed by athletes for ages now it's about as low risk a gamble as any out there.