[santiagobasulto]

This uses pyodide. It's more like a Python to JS transpiler (even if it's not). It's to create browser apps using Python. So it's Pyodide + a browser API.

[azakai]

They also support MicroPython as an option now and not just Pyodide,

https://pyscript.net/tech-preview/micropython/about.html

In fact the main PyScript site uses MicroPython now, I see in the dev console (micropython.mjs and micropython.wasm).