[deamanto]

Interesting - this looks like Beransa[1] (Librela) which is a monthly injection for canines that have osteoarthritis. My dog did not have any noticeable changes to pain after using this for 2 months so I've decided to take him off of it.

[1] - https://en.wikipedia.org/wiki/Bedinvetmab

[zukzuk]

My cat has been in the feline equivalent (Solensia/frunevetmab) for about two years, and although it had a huge positive impact for the first 12 to 18 months, it seems to have suddenly completely stopped working in the last little while.

One theory is that the immune system eventually starts attacking the monoclonal antibody med itself, another is that as in humans, the OA progression might accelerate under the drug.

[deamanto]

I also have mine on Pentosan which did have a noticeable difference for him so that's great. You could possibly talk to your vet about this, it's significantly cheaper than Beransa (110AUD/month) and for my dog it's biannual with a booster shot in between

I actually (anecdotally) heard a similar issue with Pentosan that it stops working after 12-24 months due to the immune system so you have to "time it" at an appropriate time in a dog's life. To be blunt, by appropriate I mean you'd want to start using it 12-24 before the dog is expected to pass and not at the first sign of osteoarthritis.

https://en.wikipedia.org/wiki/Pentosan_polysulfate#Dogs

[bittercynic]

I thought the same.

My dog's been on it since last October, and it's made a big difference for him. Sorry to hear that it didn't help yours.

I've been wondering how long it would be before something similar was available for humans.

[deamanto]

That's great that it works for him

On the bright side, I also have mine on Pentosan which did have a noticeable difference for him so that's great

https://en.wikipedia.org/wiki/Pentosan_polysulfate#Dogs

[dl9999]

When my dogs were alive, they had ketamine shots once a month (I think) and that seemed to help quite a bit.

[stef25]

Why is it that words ending in "mab" make me so angry? "vetmab" is the most disgusting use of 6 letters.