If you are referring to LSD you do not jest. Albert Hoffman intentionally dosed himself, although he took what would now be considered 5-10 times a typical "dose".
250µg is a robust dose of LSD, but not an unreasonable one at all. Someone with some experience who takes that amount will appear to others as obviously tripping, but ordinarily they will still make sense, be able to converse, and so on.
100µg is the usual standard of measurement, as in a drop from a vial or a square of blotter, and plenty of enthusiasts like three of those when they partake. So more like 2.5X of a 'standard dose', and well within the typical range.
I'm certain it was a remarkable experience for someone who had no idea whatsoever what they were getting into, though.
There's no known case of anyone dying from an LSD. Even after taking a few thousand times the typical amount (they thought it was cocaine). They did need hospitalization and would likely have died from aspirating their own vomit without it, however they all fully recovered within 48 hours.
It's a pretty challenging drug to hurt yourself (physically/chemically) with.
Also it does not readily absorb through the skin.
Edit: https://web.archive.org/web/20080316074056/http://www.flashb...
Apparently his first experience was accidental. His second experience was intentional, although still far higher then would be considered reasonable.