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by nostrademons 688 days ago
There are some early studies out [1] that indicate remission is possible with OIT. (For laypeople, "desensitization" ~= can tolerate some peanut exposure without a reaction, but still needs to carry an epipen and remain on the maintenance dose for life, while "remission" ~= no longer has a peanut allergy). The numbers were 71% desensitization and 21% remission for OIT vs. 2% both for a placebo. It was heavily dependent on age, with 71% of 1-year-olds, 35% of 2-year-olds, and 19% of 3-year-olds achieving remission.

Data will be scant at this time, because the full treatment takes a long time and needs to be adhered to closely. It's 30 weeks of OIT, followed by 2 years of a maintenance dose, followed by a 6-month hiatus to verify whether the maintenance dose can be stopped while still achieving remission, so data necessarily lags the start of any clinical trials by 3+ years.

[1] https://www.nih.gov/news-events/news-releases/oral-immunothe...