[cookiecaper]

Some people may need to put in a lot of work at something to become competent, but I don't believe that wholesale just some people can never succeed at something as generic as entrepreneurship unless there is a physical or mental disability or some really exceptional background involved. Most normal people really can become successful entrepreneurs if they try hard enough.

As the OP said, just saying, "You'll never make it, just give up" is very unlikely to yield positive results. So even if you think the founder really will never make it, why is that an important criticism to share? They may surprise you if you actually provide helpful criticism on action points where real progress can occur. "Stop being you" is, of course, not actionable.