[DougWebb]

T1 and T2 are completely different diseases. T2 should not be called diabetes. It should be called insulin resistance or chronic carbohydrate overdose.

I was diagnosed as pre-diabetic/T2. I started wearing a cgm and watching how various foods affected my blood sugar. I eliminated foods that caused spikes, and started cooking my own meals so I could control what went into them. I wound up with a very low carb diet of meat and vegetables, and a very stable blood sugar with NO spikes ever. According to my blood work and checkups I cured my NAFLD, cured my hypertension (including getting off drugs for that), and "cured" my pre-diabetes. I lost a lot of weight, but still have a lot more to lose.

I put cured in quotes because I don't think this diet can cure you once you're bad enough to need treatment. I think it can only put your disease into remission so that you don't suffer any health effects from it. Some of us just can't overeat carbs or we develop this disease, and the only effective treatment is to stop eating the carbs.

[fortran77]

There are some people with T2D—a minority of them—who are not overweight. I think T2D with overweight or obesity should be called something else.

[itchyouch]

It's metabolic dysfunction at its core.

Optimizing the electron transport chain via supplements like CoQ10 (Ubiquinol more bioavailable), Benfotiamine (b1 form), Nicotinamide Riboside (b3 form) are extremely helpful.

That's the reason why metformin works so well for diabetes, and has longevity extension effects, because of how it stimulates the AMPK pathway, which is also anti-inflammatory (thus lowering oxidative stress).

We can reframe a TON of chronic conditions under the umbrella of mitochondrial dysfunction, whether it's ME/CFS, T2 diabetes, anxiety, depression, and addressing the mitochondrial dysfunction tends to be extremely helpful, if not able to bring the conditions into remission.

The problem though is that addressing mitochondrial dysfunction requires a multi-pronged approach with a lot of disruptive lifestyle interventions, which makes the activation cost for such things a hump that the average person will not be able to get over unless they have enough privilege to do so.

[Aerbil313]

Please share more. This is the first time I heard of mitochondrial dysfunction. The more I read and research, the more I see this type of pattern: A host of similar diseases claimed to be caused by a very fundamental process in the body, which is only malfunctioning due to the modern lifestyle. Many of those stuff are backed by research.