[piombisallow]

Estrogen replacement increases the risk of cancer in women.

[kridsdale1]

This is not accurate and is the result of a misinterpretation of the Women’s Health study of the 2000s. It’s much more complicated. The specific type of molecule matters.

[bsder]

Citation.

Breast cancer dropped with a step function when HRT was stopped in general for meopausal women.

I haven't seen any studies to the contrary.

[digdugdirk]

Did a quick search and found this one: https://evidence.nihr.ac.uk/alert/risk-of-breast-cancer-with...

Could be worth a look? I didn't dive into the study itself, but it seems decent at a glance.

[Auracle]

There are various forms of HRT and not all cause an increase in cancer. It’s a shame that notion has stuck around when it could be so helpful for so many women: bone density, hot flashes, vaginal atrophy, etc.

They do tend to cause an increase in blood clots though. The risk is manageable in relatively fit women. In overweight/sedentary women that gets a bit harder to balance out.

[wizzwizz4]

> They do tend to cause an increase in blood clots though.

That risk factor is specific to the oral route, and/or conjugated equine oestrogens. Injections, patches etc. of synthesised oestrogens don't seem to have that problem. https://www.bmj.com/content/364/bmj.k4810

> Transdermal preparations were not associated with risk of venous thromboembolism, which was consistent for different regimens

Don't eat your HRT: rub it on your gums!