[l2silver]

In my experience, it's very rare that you're in a job that requires you to come up with a solution to a problem no one has ever dealt with before. Custom solutions are often a sign the engineers in question didn't do the appropriate research to find the standard solution for the problem.

I've been a software developer for 10 years, and I've never worked on a problem that someone else hadn't come up with a solution for somewhere. And if they haven't, alarm bells go off as to why I'm the first to do this, and where down the pipeline did I deviate so horrifically from the norm.

[mylons]

I strongly agree with this. I worked on low level algorithms in bioinformatics circa 2010. Writing mapping algorithms and variant detection in C/C++. Most/all of what we did was adapt known compression and database algorithms. The "best" aligner is still BWA (Burrows-Wheeler Aligner), which uses the Burrows-Wheeler Transform, popular in a lot of compression utilities.