[gklitz]

> The classical approach was to understand how genes transcribe to mRNA, and how mRNA translates to polypeptides; how those are cleaved by the cell, and fold in 3D space; and how those 3D shapes results in actual biological function.

Do you have references for this approach? It’s my understanding that structure solutions mostly lag drug development quite significantly and that underlying biological understanding is typically either pre-existing or will end up not existing for the drug until later. Case in point look at recent Alzheimer’s drugs where the biological hypothesis is even straight up disproven.