[knowaveragejoe]

If you are privacy conscious, yes. Compartmentalizing emails used for services is useful. It also tells you who is selling your information.

[toomuchtodo]

Also, when it is clear someone is abusing the email you provided, you can nuke it. Perhaps some functionality to be had here between aliases and haveibeenpwned detecting an alias in a breach, queuing for alias cycling or invalidation with a human approval step.