| Have to disagree. Almost all researchers have essentially unfettered access to all of biomedical literature. Access to papers is therefore a tertiary annoyance wrt progress in science and the cures for cancers. What IS a huge problem is the almost complete lack of systematically acquired quantitative data on human health (and diseases) for a very large number (1 million subjects) of diverse humans WITH multiple deep-tissue biopsies (yes, essentially impossible) that srr suitable for multiomics at many ages/stages and across many environments. (Note, we can do this using mice.) Some specific examples/questions to drive this point home: What is the largest study of mRNA expression in humans? ANSWER: The small but very expensive NUH GTEx study (n max of about 1000 Americans). This study acquired postmortem biopsies for just over 50 tissues. And what is the largest study of protein expression in humans across tissues? Oh sorry, this has never been done although we know proteins are the work-horses of life. What about lipids, metabolites, metagenomics, epigenomics? Sorry again, there is no systematically acquired data at all. What we have instead is a very large cottage-industry of lab-level studies that are structurally incoherent. Some brag about the massive biomedical data we have, but it is truly a ghost and most real data evaporates with a few years. Here is my rant on fundamental data design flaws and fundamental data integration flaws in biomedical research: Herding Cats: The Sociology of Data Integration
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2751652/ |
But I also think the GP's claim and yours are not incompatible. I wonder how much survivorship bias this has since it only considers those that are able to do research, and not those that would have but ended up doing continuing with another STEM job. We could be asking the counterfactual that I think the GP is implying: would more people have been interested in becoming cancer researchers if publications were open?
We can sort of see the effect because we have scihub now, which basically unlocks journal access for those that are comfortable with it, and I consider it plausibly having a significant effect for the population that have a research background without an academic affiliation. I've met a few biotech startup founders that switched from tech to bio and did self study+scihub outside of the university. The impetus for change I've heard a few times is a loved one got X disease, and I studied it, quit my less impactful tech job to work on bio stuff.