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did we read the same study?? https://www.nature.com/articles/s41531-024-00724-z from there: > Riboflavin (vitamin B2) in humans originates from food and gut microbiota. Therapeutically, riboflavin improves oxidative stress, mitochondrial dysfunction, neuroinflammation, and glutamate excitotoxicity, which are related to PD pathogenesis27. In a clinical study, high doses of riboflavin ameliorated motor deficits in PD patients28. In another disease, supplementation of riboflavin in patients with Crohn’s disease decreased systemic oxidative stress, inflammatory effects, and disease activity29. Supplementation of riboflavin to compensate for decreased riboflavin production by gut microbiota may be beneficial in PD patients. > Biotin (vitamin B7) produces anti-inflammatory substances and decreases inflammation, which leads to the relief of allergy, immunological symptoms, and inflammatory bowel disease30. The effects of biotin on PD have not been reported to the best of our knowledge. In contrast, in multiple sclerosis, open31 and double-blind32 studies showed that biotin ameliorated motor and optical defects. now these supplements are the tentative suggestion in the article. what you _may_ validly point out is that these supplements are only identified as of _potential_ helpt, because follow up studies are needed to validate if this really is the case. but neither the study nor the article claim otherwise, right? |