[dekhn]

This is a bit pedantic, but: AF says little to nothing about protein "folding". It is focused on static structure prediction. The history of this is a bit muddy but if you follow the details carefully you'll see that "protein folding" is a term that references the physical process by which proteins adopt their "final" conformations (or more accurately, interconvert between a bunch of accessible conformational states), while static structure prediction only cares about the final conformational state (possibly states).

Although many people say "protein folding problem" that's really referring to a different and far more complex problem than static structure prediction. What is the exact trajectory that a protein follows when moving from the fully unfolded state to the final states? What forces dominate that process? How do proteins overcome large barriers so quickly? To what extent does the cost of interacting with water dominate? What are the rates at which fully folded proteins interconvert between substates? Which proteins will never fold on their own, why, and how do they get folded by other proteins?